University of Pittsburgh Identifies the Molecular Mechanisms Behind Resilience to Noise-induced Tinnitus.

The University of Pittsburg has been behind some significant breakthroughs in tinnitus drug research. Their earlier work resulted in the development of KCNQ2/3 specific activators that can prevent the development of tinnitus in mice after noise exposure. Their latest paper shows that HCN channels also contribute and they are now looking to target those in combination with KCNQ2/3 channels to more effectively address vulnerability and resilience to tinnitus. Some suspect that tinnitus and hyperacusis are related, leading to curiosity that a successful tinnitus medication may improve hyperacusis symptoms.

News Release: http://www.eurekalert.org/pub_releases/2015-08/uops-pti082715.php
Journal Article: http://elifesciences.org/content/early/2015/08/27/eLife.07242

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