The University of Oxford in England has identified a region of the brain that “is likely responsible for the core ‘it hurts’ experience of pain.” The region is the insular cortex.
Press Release: http://medicalxpress.com/news/2015-03-ouch-zone-brain.html
Study (Not Free): http://www.nature.com/neuro/journal/v18/n4/full/nn.3969.html